| abstract |
The present invention relates to the combination of the progesterone-receptor antagonist 11β (4-acetylphenyl)-17β -hydroxy-17α -(1, 1, 2, 2, 2-pentafluoroethyl)-estra-4, 9-dien-3-one or a pharmaceutically acceptable derivative or analogue thereof, together with at least one none-steroidal antiestrogen and to the use of said combination for the prophylaxis and treatment of BRCA1-or BRCA2-mediated diseases. None-steroidal antiestrogenes which can be combined together with the progesterone-receptor antagonist 11β -(4-acetylphenyl)-17β -hydroxy-17α -(1, 1, 2, 2, 2-pentafluoroethyl)-estra-4, 9-dien-3-one are for example is tamoxifen, raloxifene, droloxifen, toremifen, lasofoxifen, arzoxifen, GW5638, EM-800, idoxifen and basedoxifene. |