| abstract |
Biotinylated heparins, characterized in that the constituent polysaccharides of the said heparins have at their reducing end a covalent bond to a group -(R1)i- Biot and correspond to the general formula (I): in which i is equal to 0 or 1, R1 represents a sequence of formula -CO-(CH2)j-NH- or -CO-(CH2)j-NH-CO-(CH2)k-NH, in which j and k are integers that may take any value from 1 to 10, Biot represents a biotin group or biotin derivative, n represents an integer with a mean value of about 25 for a heparin with an average molecular mass of 15000 Da, X represents H or SO3Na, Y represents COCH3 or SO3Na, and the wavy line denotes a bond located either below or above the plane of the pyranose ring to which it is attached. Preparation process therefor and therapeutic use thereof. |