http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-200848416-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d834913e5849d860f48c002b1519e5b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-352 |
| filingDate | 2007-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0599ae4ded7a7f4632b279bbb0ce09f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_865f401c572d32493ff608ea14598220 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02c924b980745abf9376a05e1384c56e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d1e53aecdfd8732825324ca4304ee7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4d93cf84a45624964219207e50ae8f9 |
| publicationDate | 2008-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-200848416-A |
| titleOfInvention | Cyclic amine derivatives and their uses |
| abstract | Compounds of formula (I) have muscarinic M3 receptor modulating activity; wherein R1 is C1-C6-alkyl or a hydrogen atom; and R2 is a hydrogen atom or a group -R5, or a group, -Z-Y-R5, or a group -Z-NR9R10, or a group -Z-N(R9)C(O)R11; and R3 is a lone pair, or C1-C6-alkyl; R4 is selected from one of the groups of formula (a), (b), (c) or (d); Z is a C1-C16-alkylene, C2-C16-alkenylene or C2-C16-alkynylene group; Y is a bond or oxygen atom; R5 is an C1-C6-alkyl, aryl, arylalkyl; aryl-fused-cycloalkyl, aryl-fused-heterocycloalkyl, heteroaryl, aryl(C1-C8-alkyl)-, heteroaryl(C1-C8-alkyl)-, cycloalkyl or heterocycloalkyl group; R6 is C1-C6-alkyl or a hydrogen atom; R7a and R7b are a C1-C6-alkyl group or halogen; n and m are independently 0, 1, 2 or 3; R8a and R8b are independently selected from the group consisting of aryl, aryl-fused-heterocycloalkyl, heteroaryl, C1-C6-alkyl, cycloalkyl and hydrogen; R8c is -OH, C1-C6-alkyl, hydroxy-C1-C6-alkyl, or a hydrogen atom; R8d is C1-C6-alkyl or a hydrogen atom; R9 and R10 are independently a hydrogen atom, C1-C6-alkyl, aryl, aryl-fused-heterocycloalkyl, aryl-fused-cycloalkyl, heteroaryl, aryl(C1-C6-alkyl)-, or heteroaryl (C1-C6-alkyl)- group; or R9 and R10 together with the nitrogen atom to which they are attached form a heterocyclic ring of 4-8 atoms, optionally containing a further nitrogen or oxygen atom; R11 is C1-C6-alkyl or a hydrogen atom; Ar1 is aryl, heteroaryl or cycloalkyl; Ar2 are independently aryl, heteroaryl or cycloalkyl; and Q is an oxygen atom, -CH2-, -CH2CH2- or a bond. |
| priorityDate | 2006-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 463.