abstract |
The present invention provides a novel compound, which inhibits the interaction of the Mdm2 (murine double minute 2) protein and the p53 protein, and shows the antitumor or activity. This invention provides an imidazothiazole derivative of the following formula (1) with various substituents (wherein, R1, R2, R3, R4, and R5 are the same as defined in the detailed statement respectively), which inhibits the interaction of the Mdm2 (murine double minute 2) protein and the p53 protein, and shows the antitumor activity. |