| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8bd7a45a343acd10e3f5d8775dda2157 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2851
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56983
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56972 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate |
2006-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3d67480594d78de7460384f2943173f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2bbc98532b518b5193b486e380e6f66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc9a18cf631740b05580b9b3d4981945
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2efe0ba85656ac42397cf8693476274d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87b7dc0d25b64ef1cd178c72e000a77c |
| publicationDate |
2008-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-200806691-A |
| titleOfInvention |
Methods and reagents for the analysis and purification of polysaccharides |
| abstract |
The disclosure provides fusion proteins comprising a carbohydrate recognition domain of an innate immunity receptor and a heterologous polypeptide. The fusion proteins of the disclosure may be used, for example, to fingerprint polysaccharide compositions and to purify polysaccharide compositions, including polysaccharide compositions isolated from Ganoderma lucidum (Reishi). The methods and reagents of the disclosure may also be used to identify innate immunity receptors and cell types that bind to polysaccharide compositions (including polysaccharide compositions associated with pathogens), whereupon modulators of the identified receptors can then be obtained. The fusion proteins also may be used to inhibit the interaction between a polysaccharide composition and an innate immunity receptor on a cell surface. The methods and reagents of the disclosure are used in one embodiment to determine that the CLEC5A/MDL1/DLVR1 innate immunity receptor on macrophages interacts with Dengue virus (DV), and that CLEC5A/MDL1/DLVR1 is responsible for DV-mediated secretion of proinflammatory cytokines from macrophages. The disclosure also provides CLEC5A/MDL1/DLVR1 antibodies that prevent the secretion of proinflammatory cytokines by DV-infected macrophages. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I403586-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11591557-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113713105-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I802558-B |
| priorityDate |
2005-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |