| abstract |
To provide novel compound having S1P recepter agonist activation, having a beneficial effect as immune suppressor, having few side-effects and being orally-bioavailable, and medicine containing of the same. A compound represented by general formula (I) [In this formula, V represents-NH-CO-or-CO-NH-, A represents -COOR7 (R7 represents hydrogen atom or alkyl group.) and the like; R1, R2, R3 and R4 represent hydrogen atom, hydroxyl group, amino group or alkyl group, respectively; R5 and R6 represent hydrogen atom, halogen atom, alkyl group or alkoxy group, respectively; Q represents -CH2O-, -CH2-CH2-, -CH=CH-, -CH2-O-N=CR8-, -CONR9-, -NR10CO-, -CH2NR11CO- or -CH2CH2NR12CO-; Y and Z represent group constituting benzene or aromatic heterocycle], salt thereof or solvate thereof and medicine containing the same. |