http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-200800192-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a9e6421e9257148abad101e1ce6c162 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 |
| filingDate | 2006-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54e62c06ae29d5593027bff747761a99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae376f8e5d192cd3a1d3d723ff26bd05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58788bc22a57c07ce0f946c9dab99c10 |
| publicationDate | 2008-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-200800192-A |
| titleOfInvention | 1-Aminoisoquinoline derivatives, preparation thereof and therapeutic application thereof |
| abstract | The invention relates to 1-aminoisoquinoline derivatives of general formula (Igr;) in which, R=H, C1-5-alky1, C1-3-fluoroalkyl, C3-6-cycloalkyl, C1-3-alkylene-C3-6-cycloalkyl, -C(O)-C1-5-alkyl, -CH2-C-CH,C2-4-alkylene-NRaRb or C1-3-alkylene-X-C1-3-alkyl in which X=O or SO2; R1= optionally substituted aryl or heteroryl; R2= H or group C1-5-alkyl; R4= H, C1-5-alkyl, C1-3-fluoroalkyl, C3-6-cycloalkyl, C1-3-alkylene-C3-6-Cycloalky1, C1-3-alkylene-O-C1-3-alkyl, C1-3-alkylene-(OH) or C1-3-alkylene-X-C1-3-alky1 in which X=S, SO or SO2, or alternatively R4=C1-3-alkylene-NRaRb, aryl, C1-3-alkylene-aryl, C1-3-alkylene-O-aryl, C1-3-alkylene-O-C1-3-alkylene-aryl, heteroaryl or C1-3-alkylene-heteroaryl, which are optionally substituted or altermatively R4=heterocycle optionaly substituted with a group C1-3-alkyl, -C(O)-C1-5-alkyl, -C(O)-C1-5-fluoroalkyl, C1-3-alkylene-C3-5-cycloalkyl, C1-3-alkylene-aryl or C1-3-alkylene-heteroaryl, which are optionally substituted; R7=H, halogen, C1-5-alkyl, C1-3-fluoroalkyl, C1-5-alkoxy, C1-3-fluoroalkoxy, C1-3-alkylene-(OH), -CN, -COOH, -C(O)O-C1-3-alkyl, -NO2 or -X-C1-3-alkyl in which X=S, SO or SO2, or alternatively R7=-NRaRb, C1-3-alkylene-NRaRb, -C(O)-NRaRb, -C(O)-C1-3-alkyl, aryl, -O-aryl or heteroaryl, which are optionally substituted; Rp and R'p=H or C1-5-alkyl, or alternatively Rp and R'p together form a single bond or C1-4-alkylene; in the form of base or of acid-addition salt, and also in the form of hydrate or solvate. Preparation process therefor and therapeutic use thereof. |
| priorityDate | 2005-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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