http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-200736251-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 |
| filingDate | 2006-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d361c8cd448909c6953bdb08cd51e78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9a7fd2923c9bdbac3f262bd97957c0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d765946d0f18275765aa09d565a13c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd53ce2c4146d033830f604a531158d1 |
| publicationDate | 2007-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-200736251-A |
| titleOfInvention | Aryl-isoxazol-4-yl-imidazole derivatives |
| abstract | The present invention is concerned with aryl-isoxazol-4-yl-imidazole derivatives of formula I: wherein R1 to R3 are each independently hydrogen or halogen; R4 is hydrogen, lower alkyl, cycloalkyl, -(CH2)n-O-lower alkyl or lower alkyl substituted by hydroxy; R5 is -(CH2)m-aryl or -(CH2)m-heteroaryl which are optionally substituted by one or more substituents selected from the group consisting of halogen, cyano, nitro, lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkyl substituted by halogen, -C(O)-lower alkyl, -C(O)-O-lower alkyl, -NH-C(O)-O-lower alkyl or -C(O)-NH-R', wherein R' is lower alkynyl or lower alkyl substituted by halogen, or is -(CH2)n-cycloalkyl, -(CH2)n-heterocyclyl, -(CH2)n-heteroaryl or -(CH2)n-aryl, optionally substituted by halogen; R6 is hydrogen, -C(O)H, -(CH2)n-O-lower alkyl, -C(O)O-lower alkyl, lower alkyl substituted by hydroxy or halogen, or is cycloalkyl, aryl, or is -(CH2)n-O-CH2-aryl, optionally substituted by halogen or lower alkyl, or is -(CH2)n-O-CH2-heteroaryl, optionally substituted by halogen, lower alkyl or lower alkyl substituted by halogen, or is -(CH2)n-NH-(CH2)o-heterocyclyl; n is 0, 1, 2, or 3 m is 0 or 1; o is 1, 2 or 3; as well as with pharmaceutically acceptable acid addition salts thereof. It has been found that this class of compounds show high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease. |
| priorityDate | 2005-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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