| abstract |
This invention provides a compound useful as a preventive or therapeutic agent for sexual-hormone-dependent diseases and the like. Namely this invention provides a fused heterocyclic derivative represented by the following general formula (I), a medicinal composition containing the derivative and a medicinal use thereof and the like. In the formula (I), ring A is a five-membered cyclic unsaturated hydrocarbon or five-membered heteroaryl group; RA is halogeno, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl group, etc.; ring B is a aryl or heteroaryl group; RB is halogeno, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl group, etc.; E1 and E2 each is oxygen, etc.; U is a single bond or alkylene; and X is a group represented by Y, -SO2-Y, -O-(alkylene)-Y-, or -O-Z (wherein Y is Z, amino, etc. and Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.). |