| abstract |
The invention relates to novel products of formula (I): in which A1, A2, A3 and A4 represent CRa or N; R1 and R1' are such that one of them represents H, Hal, C1C3-alkyl, C1C3-alkoxy, alkyl-OH, CF3, cyano, carboxy or carboxamido; and the other one represents H; Hal; CF3; OH; SH; nitro; amino; NH-OH; NH-CO-H; NH-CO-OH, NH-CO-Oalkyl, NH-CO-NH2; carboxy; CN; CO-NH2; X-(CH2)m-alkyl; X-(CH2)m-cycloalkyl; X-(CH2)m-heterocycloalkyl; X-(CH2)m-aryl or X-(CH2)m- heteroaryl with X=single bond, CH2, CH=CH, CH2-O, CH2-NH, CH2-C(O), CH2-C(O)-O, CH2-C(O)-NH, CH2-NH-(CO), CH2-NH-S(O), CH2-NH-S(O)2, O, S, NH, O-C(O), C(O)-NH, -NH-C(O), -NH-C(O)-C(O)-, -NH-C(O)-NH-.; NH-CS, NH-S(O) or NH-S(O)2; m=0, 1 or 2; either R1 and R1' form, with C to which they are bound, either an =O; =S; =N-OH; =N-NH2; =N-NH-CO-NH2, =CH-OH; =Y1-(CH2)m-aryl or =Y1-(CH2)m -heteroaryl radical, where Y1 represents CH, CH-CO-, CH-CO-NH, N, N-O or N-NH-, with m=0, 1 or 2, or a ring, R2 and R2', represent H, halogen, CF3, nitro, cyano, alkyl, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, aikylthio, free or esterified carboxy, carboxamide, CO-NH(alkyl) and CO N(alkyl)2, p= 1 to 3 and p'= 1 to 4; Ra represents H; halogen; CF3; hydroxy; mercapto; nitro; amino; NH-OH; NH-CO-H; NH-CO-NH2; carboxy; CN; CO-NH2; Y-(CH2)n-alkyl; Y-(CH2)n-cycloalkyl, Y-(CH2)n-heterocycloalkyl, Y-(CH2)n-aryl or Y-(CH2)n-heteroaryl, with Y=O, S, NH, O-C(O), C(O)-NH, NH-C(O), NH-S(O) or NH-S(O)2, with n=0, 1, 2 or 3, all the alkyl, alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, aryl and heteroaryl radicals being optionally substituted, said products being in all the tautomeric and isomeric forms and the salts, as medicinal products. |