| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59e1d955a7b1560dc68cf7fd800e8fac |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J3-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L5-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0072
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J3-122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| filingDate |
2005-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de2de41e833228cdb10d0a3e1e5112f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af4244b8eb0d9902c264cdd7e57df924
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01be85f4a8abd6f81a7b0fd17b32617e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_011a897329f3bc958529c4dd5548c3d5 |
| publicationDate |
2006-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-200612991-A |
| titleOfInvention |
Process for producing water-soluble hyaluronic acid modification |
| abstract |
A water-soluble hyaluronic acid modification practical to be a drug carrier, and a process for producing the modification is provided. The water-soluble hyaluronic acid modification is produced by incorporating substituents into carboxy groups of the glucuronic acid moieties in either hyaluronic acid or a derivative thereof through an amide bond with the aid of a BOP condensation agent in an aprotic polar solvent, the amount of the substituents being at least 5 mol%. This modification can reside in the blood in a prolonged period on a practical level. By crosslinking the hyaluronic acid modification gives a hyaluronic acid gel. This gel can release a drug over a far longer period than known gels even when the proportion of crosslinkable functional groups introduced is the same. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8946305-B2 |
| priorityDate |
2004-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |