| abstract |
Compounds of the formula (I): [wherein, Q represents an oxygen atom, a C1-3 alkylene group, -O-Alk- or -O-Alk-O-(Alk- represents a C1-3 alkylene group); R1 represents an optionally substituted C1-20 alkanoyl group, an optionally substituted C3-20 alkenoyl group or an optionally substituted C3-20 alkynoyl group; R2, R3 and R4 maybe the same or different, each represents a hydrogen atom, an optionally substituted C1-20 alkyl group, an optionally substituted C2-20 alkenyl group, an optionally substituted C2-20 alkynyl group, an optionally substituted C1-20 alkanoyl group, an optionally substituted C3-20 alkenoyl group or an optionally substituted C3-20 alkynoyl group; R5 represents a hydrogen atom, a halogen atom, a hydroxy group, an optionally substituted C1-6 alkoxy group, an optionally substituted C2-6 alkenyloxy group or an optionally substituted C2-6 alkynyloxy group; W represents an oxygen atom or -NH-], or the pharmaceutically acceptable salts thereof, which have the excellent macrophage activity suppressive effects are disclosed. |