| abstract |
It is intended to provide tumor necrosis factor mutant proteins, in particular, tumor necrosis factor mutant proteins specific for TNF-R1 or TNF-R2, and tumor necrosis factor inhibitors or tumor necrosis factor preparations comprising the same as the active ingredient. This object can be achieved by providing a tumor necrosis factor mutant protein having an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO:1 in Sequence Listing by the substitution of one or more amino acid residues at the 29-, 31-, 32-, 145-, 146- and 147-positions (counted from the N-end) and the amino acid residues at the 84- to 89-positions by other amino acid residue(s) and a tumor necrosis factor inhibitor or a tumor necrosis factor preparation comprising the same as the active ingredient. |