| abstract |
Provided is a compound represented by Formula (I), which is specific to and capable of strongly inhibiting the activity of GSK-3 while being clinically applicable and a medically acceptable salt thereof: wherein X is O or S; A1 is - or aliphatic hydrocarbon; A2 is -, CO, COO, CONR, CSNR, C(NR), O, OCO, NR, NRCO, NRSO2, NRCOO, NRCONR, NRCS, NRCSNR, S, SO, SO2, SO2NR, CR=CH, CR=CF, CH=CR or CF=CR; G1 is -, hydrocarbon or heterocyclic; A3 is - or aliphatic hydrocarbon; A4 is -, CO, COO, CONR, CSNR, C(NR), O, OCO, NR, NRCO, NRSO2, NRCOO, NRCONR, NRCS, NRCSNR, S, SO, SO2, SO2NR or SO2O; G2 is H, hydrocarbon or heterocyclic; A5 is - or NR; R2 is H, F, Cl, Br, I, hydrocarbon or heterocyclic; A6 is -, NR, CO, NRCO, NRCS, NRCONR, CONR, NRCH=N, COO, OCO, O, S, SO, SO2, CR=CR, NCR, C≡C or SO2C≡C; R3 is H, F, Cl, Br, I, nitro, hydrocarbon or heterocyclic; and, in A6-R3, A6 is CR=CR or C≡C, and R3 is a trimethylsilyl, formyl, acyl, carboxyl, alkoxylcarbonyl, carbamoyl, alkylcarbainoyl or cyano; and R is H or an aliphatic hydrocarbon. |