| abstract |
This invention is to provide an anti-activated protein C (aPC) antibody which inhibits the inactivation of aPC and utilization thereof. By screening anti-aPC antibody, an anti-aPC antibody having an activity of inhibiting the inactivation of aPC in the blood is successfully isolated. Via the inhibition of the inactivation of aPC, this antibody is usable in maintaining the aPC activity and sustaining the physiological effects (for example, an effect of inhibiting the activation of the blood coagulation system, an anti-inflammatory effect, etc.) of aPC. It is also intended to provide utilization of the above antibody in treating thrombosis, sepsis, etc. with the use of aPC. In the administration of aPC for a therapeutic purpose, the therapeutic effects can be prolonged by bonding the antibody as described above to aPC. This antibody is useable in treating and preventing thrombosis, sepsis, etc. |