| abstract |
The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I), in which: - n is 1 or 2; - R1 represents a halogen atom; a trifluoromethyl radical; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethoxy radical; - R2 represents a hydrogen atom or a halogen atom; - R3 represents a hydrogen atom; a group -OR5; a group -CH2OR5; a group -NR6R7; a group -NR8COR9; a group -NR8CONR10R11; a group -CH2NR12R13; a group -CH2NR8CONR14R15; a (C1-C4)alkoxycarbonyl; a group-CONR16R17; - or else R3 constitutes a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; - R4 represents the aromatic group 1,3-thiazol-2-yl of formula: Preparation process and therapeutic application. |