http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-200404100-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a01717442a2a920617ac88dbdf9caacc |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2003-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3a49d3748ae0b9c7d8825abf888bbd3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b0b591b9842483362bc1da8fa52636c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30080fea368ef7e6453636d5d5772a6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4f058f8b9d139cdc4c85ebc4b2f4f5f |
| publicationDate | 2004-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-200404100-A |
| titleOfInvention | Methods for analyzing sorbs1 polymorphisms and use in diagnosis of predisposition to insulin disorders and treatment of insulin disorders |
| abstract | The present invention identifies mutations in the human sorbin and SH3-domain-containing-1 (SORBS1) gene, particularly at one or more of positions 220, 249, -7 with respect to exon 5, -25 with respect to exon 6, 682, +64 with respect to exon 9, +61 with respect to exon 10, +69 with respect to exon 11, +33 with respect to exon 16, 1482, 1518, -6 with respect to exon 22, +79 with respect to exon 24, and 2337. A polymorphism at position 682 within exon 7, the T228A allele, correlates with the phenotypes of low blood pressure and low body mass index, and is a protective marker for both obesity and diabetes. The invention also relates to methods and materials for detecting single nucleotide polymorphisms in the SORBS1 gene and to the use of SORBS1 polymorphisms in the diagnosis, screening, and treatment of type 2 diabetes, obesity, hypertension, atherosclerosis, and metabolic syndrome. The invention is predicated on the identification of the human SORBS1 gene. |
| priorityDate | 2002-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 226.