http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-200404079-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J51-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-305 |
| filingDate | 2003-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c120664c87ed69a9323111c610784375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a657bbb983ced02eb41dd4e12d09d9c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fc5ddb0dc1b2101cfbaf44ed9d9a1a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_787eda261c70942bb98425861a4956b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da4db8e77e8dbe221680df55cac35a9a |
| publicationDate | 2004-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-200404079-A |
| titleOfInvention | Processes to prepare EPLERENONE |
| abstract | The present invention involves intermediates, including a 7α-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent. A process for the preparation of a Δ<SP>4,6</SP>-ketal of formula (I-P), where R31 and R32 are (1) the same or different and are C1-C3 alkyl, and (2) taken with the attached -O-C-O- to form a cyclic ketal of 5 or 6 atoms of the formula -(CH2)-(CR33R34)n1-(CH2)- where n1 is 0 or 1; where R33 and R34 are the same or different and are -H, C1-C3 alkyl, which comprises (1) contacting a Δ<SP>3,5</SP>-3-enol ether of formula (Alkyl enol ether), (Alkyl enol ether) where R3 is C1-C3 alkyl, CH3-CO-, Φ-CO- or Rsi-1R-Si-2RSi-3Si- where Rsi-1, Rsi-2 and Rsi-3 are the same or different and are C1-C4 alkyl; with a hydride abstractor and an alcohol selected from the group consisting of alcohols of the formula: (a) R31-OH, where R31 is as defined above, (b) R32-OH, where R32 is as defined above, (c) HO-(CH2)-(CR33R34)n1-(CH2)-OH where n1, R33 and R34 are as defined above, (d) HO-CH2-CH2-OH. |
| priorityDate | 2002-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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