| abstract |
Preventive and/or therapeutic drugs for neuro-degenerative diseases including Alzheimer's disease, which contain as the active ingredient substances selected from the group consisting of compounds represented by the general formula (I), pharmacologically acceptable salts thereof, and hydrates and solvates of both: (I) wherein A is hydrogen or acetyl; E is 2,5- or 3,5-disubstituted phenyl or an optionally substituted monocyclic or fused -polycyclic heterocyclic group (exclusive of (1) fused-polycyclic heteroaryl whose benzene ring is bonded directly to the -CONH- group, (2) unsubstituted thiazol-2-yl, and (3) unsubstituted benzothiazol-2-yl); and ring Z is compound which may have a substituent in addition to the groups represented by the general formulae: -O-A (wherein A is as defined above) and -CONH-E (wherein E is as defined above) or heteroaryl group which may have a substituent in addition to the groups represented by the general formulae: -O-A (wherein A is defined as above) and -CONH-E (wherein E is as defined above). |