| abstract |
The present invention relates to novel processes for the preparation of combretastatins by a Wittig condensation between the nitromthoxybenzaldehyde and a trimethoxybenzyl phosphonium salt or, the reverse, a nitromethoxybenzyl phosphonium salt with the trimethoxybenzaldehyde, or a Wittig reaction on the same derivatives, the nitro functional group of which has been reduced to an amino group. |