| abstract |
An agent for treating or preventing a rennal glomeralus disfunction comprises, as the active component, a compound of the formula (I): [wherein R1, R2: H, optionally substituted lower alkyl, optionally substituted aralkyl etc.; R3: 1, 4-phenylene or 2, 5-thiophendiyl; R4: (R5: H, optionally substituted amino etc.) Y: NHOH OR OH] or the optically active substance, or the pharmaceutically acceptable salt or hydrate thereof. |