| abstract |
The pharmaceutical compositions comprising azetidine derivatives of formulae (Ia) or (Ib) are particularly advantageous because of the high affinity of these derivatives for cannabinoid receptors. A stable pharmaceutical composition comprising at least one azetidine derivative of general formula: in which Ar is an aromatic or heteroaromatic group optionally substituted with one or more (C1-C4)alkyl, halogen, NO2, CN, (C1-C4)alkoxy or OH groups, optionally in combination with another active ingredient capable of potentiating the effects of the azetidine derivative of general formula (Ia) or (Ib), in a system comprising at most 2 principal excipients chosen from a nonionic surfactant with a hydrophilic character capable of solubilizing the azetidine derivative of general formula (Ia) or (Ib) and, where appropriate, the active ingredient potentiating the effects of the azetidine derivative, and capable of causing the formation of a colloidal system, optionally supplemented with a second excipient of a lipophilic nature, stabilizing the formulation. |