| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_39bf0bb8b07e151d4bcead749d7dd699 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-6037
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-734 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0081
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1285
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-646
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0063
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-095 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-09 |
| filingDate |
2012-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1349ba02596e663f6877227eede841d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10ed7049711e1adb417b0613f57b6d66 |
| publicationDate |
2019-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TR-201909110-T4 |
| titleOfInvention |
Methods for making saccharide-protein glycoconjugates. |
| abstract |
The invention provides a process for the reductive amination of a carbonyl group at the reductive terminal of a polysaccharide; wherein the reductive amination is carried out at a pH between 4 and 5. The invention also provides a process for preparing a conjugate comprising a polysaccharide and a carrier molecule, comprising the steps of: (a) coupling the polysaccharide to a linker to form a polysaccharide-linker compound where the free terminal of the linker is an ester group; and (b) reacting the ester group with a primary amine group in the carrier molecule to form a polysaccharide-linker-carrier molecule conjugate in which the linker is attached to the carrier molecule via an amide linkage. The invention also provides a process for reducing unreacted binder contamination in a polysaccharide-linker compound, comprising a step of precipitating unreacted binder at a pH of less than 5 under aqueous conditions. The invention also provides polysaccharide-linker-carrier molecule conjugates and intermediates obtained or obtainable by these processes. |
| priorityDate |
2011-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |