| abstract |
Combinations of a hyaluronan degrading enzyme such as a hyaluronidase and an immune system checkpoint inhibitor are provided. The combinations are used to enhance any therapy, particularly anti-tumor therapy, including immune system checkpoint inhibitors or other inhibitors of immunosuppressive effects on tumors. Combination therapy is for use in the treatment of cancers, including solid and non-solid tumors. Methods of treating cancers are also provided. |