| abstract |
This patent describes a method for the resolution of 4- [4- (dimethylamino) -1- (4'-fluorophenyl) -1-hydroxybutyl] -3- (hydroxymethyl) -benzonitrile to its isolated enantiomers in the form of a racemic or non-racemic enantiomer mixture. said method in a solvent system comprising acetonitrile, using 0, (9'-di- / 7-toluoyl- (S, S) -tartaric acid (+) - (S, S) - or (-) - (R, R) ) -enantiomer and the fractional crystallization of 4- [4- (dimethylamino) -1- (4 'fluorophenyl) -1-hydroxybutyl] -3- (hydroxymethyl) -benzonitrile in salt form. |