| abstract |
The invention is a compound of formula (I) wherein R 1 is a cercar; R2 is-CH2-O- (R7) m, R7 represents a sugar, or R2-COOH; R3 is an epoxide-containing group, C1-C6-alkyl or C2-C6-alkyl or C2-C6-alkenyl, unsubstituted or at least substituted with an OH; R5 is H, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl; R4, R6, R8 and R10 are independently H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, X2H, or -X2R12, or R4 and R6 together and / or R8 and R10 together = X2; X2 is O, NH, N-C1-C6-alkyl, N-C2-C6-alkenyl, N-C2-C6-alkynyl or S; R12 is C1-C6-alkenyl, C2-C6-alkynyl, C2-C6-alkynyl, aryl or acyl; and m and n are 1 or 2; and physiologically acceptable salts thereof. The compounds can be obtained by fermentation from the culture of microorganism actinomycetals strain HAG 003959, DSM 12931. Accordingly, the invention relates to their preparation and to the use of the compounds, for example, as anti-tumor agents. FORMULA |