| abstract |
n is from 1 to 5; X is N or C-R5 (wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl, or heteroaryl); Z is a heteroaryl group; Heterocyclic is provided, which are sodium / proton exchange (NHE) inhibitors having structure (I) where R, R, R and R4 are as defined herein and X is N, R is preferably aryl or heteroaryl. and it is useful as cardio preservatives. Also provided is a method for the prevention or treatment of angina pectoris, cardiac dysfunction, myocardial necrosis and arrhythmia using the above heterocyclic derivatives. |