| abstract |
The six-element aromatic nitrogen ring compounds or pharmacologically acceptable salts of the general formula (1) exhibit superior inhibitory activity against PDE V and are useful as preventive or therapeutic drugs for inadequate penile erection and similar problems. In formula (I); A is an optionally substituted nitrogen heterocyclic group; R1 is an optionally substituted lower alkyl, R3 is an optionally substituted nitrogen heterocyclic group; and an NH-Q-R3 wherein R is lower alkylene or a single bond, or an NH-R4 group wherein R4 is an optionally substituted cyclo alkyl; R2 is an optionally substituted aryl; and one of Y and Z = CH-, the other is = N-. |