| abstract |
The present invention relates to compounds of formula (I), N-oxide forms, pharmaceutically acceptable addition salts, and their stereochemical isomeric forms, each of which is independently hydrogen, halogen, C1-6alkyl, nitro, hydroxy. or C1-4alkyloxy; Alk is C1-6alkanediyl; n is 1 or 2, p is 0, 1 or 2; The central alpha2-adrenoceptor antagonist activity of D is heterocyclic, an optionally substituted single, double or triple ring nitrogen. It also relates to their preparation, pharmaceutical use, and combinations. (FORMULA VAR) |