| abstract |
A pharmaceutical composition in tablets or capsules provides a combination of temporary and intermittent control of the drug administered to a patient for effective therapeutic results. The pharmaceutical composition includes a drug, a gas-producing component, an embossing agent, a viscolyting agent, and optionally a gel-forming polymer. The embossing agent belongs to a compound class known as super separators. (eg crosslinked polyvinylpyrrolidone or sodium carboxymethylcellulose). The viscolyzing agent is initially and the gel-forming polymer then forms a hydrated gel matrix that traps the vagina, causing the tablet or capsule to float, thereby keeping it in the stomach or upper part of the small intestine (intermittent control). At the same time, the hydrated gel matrix creates an immediate spreading path for the drug and allows the drug to be released continuously (temporary control). Preferred one-time ciprofloxacin formulation, 69.9% ciprofloxacin base, 0.34% sodium alginate, |