| abstract |
The invention relates to the compounds of the general formula below FORMULA where X and R5 together are> N (CH2) 2-; or X and R3 together are> N (CH2) 3-; or R8 is hydrogen or lower alkyl, and their pharmaceutically acceptable acid addition salts, except for the following compounds. (6-Chloro-2-phenyl-4-quinolinyl) - (+) - 2-aminobutanol; (6-methyl-2-phenyl-4-quinolinyl) - (+) - 2-aminobutanol; (6-methoxy-2-phenyl-4-quinolinyl) - (+) - 2-aminobutanol; and (8-methoxy-2-phenyl-4-quinolinyl) - (+) - 2-aminobutanol, these compounds can be used in the treatment of diseases associated with NMDA receptor specific blockers. |