| abstract |
A method for the expression of sulfanyl type endothelin receptor antagonists of general formula (I), wherein R1 hydroxy, alkoxy, sulfonamidyl, amino, R2 alkyl, aryl and heteroaryl are substituted when necessary, and R3, R4, R5 are equal or independent of each other. as, alkyl or aryl may be substituted when a carbonic acid derivative of formula II is required by the nucleophil reaction with a sulfur of formula III; in this case X SR6 or SO2R6 and R6 alkyl or aryl may be substituted with endothelin receptor antagonists of formula I, if required. |