| abstract |
New compounds of Formula (I) are presented such that A is a benzo ring, which is a six-membered heterocyclic aromatic ring containing 1-3 nitrogen atoms, or selected from O, N and S, which may be the same or different. represents a five-membered heterocyclic aromatic ring containing heteroatoms; R1, R2, R3, and X as well as their pharmaceutically acceptable salts, enantiomers and tautomers have been identified. their preparation, their combination and their use in therapy. These combinations are inhibitors of nitric oxide synthase and are therefore particularly useful in the treatment of inflammatory disease and pain, or prevention from these diseases and pain. |