| abstract |
THE INVENTION RELATES TO A PROCESS AND INTERMEDIATES FOR PREPARING CYCLOALCANO-INDOLECARBOXYLIC ACIDS AND AZAINDOLECARBOXYLIC ACIDS AND PYRIMIDO (1, 2-a) INDOLECARBOXYLIC ACIDS THAT ARE IN AN ENHANCED SIGHT, AND THEIR ENTIRETY ACTIVITY, TOLYLACETIC ACID IS FIRST ESTERIFIED WITH A CHIRAL ALCOHOL, THEN THERE IS A DIASTERIOSELECTIVE SUBSTITUTION AT THE LEVEL OF CARBON ATOMS ل, THIS PRODUCT IS HALOGEN IN THE TOLYLE GROUP THEN BEING REACTIVATED WITH CYCLOALCOLANCANCOLANCOL OR APPROPRIATE PYRIMIDO (1,2-a). THIS PROCESS ENABLES PREPARATION WITH HIGH PURITY CARBOXYLIC ACIDS PURE FROM AN ENANTIOMERIC VIEW, WHICH ARE INTERMEDIATES FOR MEDICINES OF HIGH VALUE. |