http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TN-SN07471-A1

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filingDate 2007-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_729d1a81c0e6a0ca8f528990023c97d3
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publicationDate 2009-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber TN-SN07471-A1
titleOfInvention Novel 2,4 - dianilinopyrimidine derivatives, the preparation thereof, their use as medicaments, pharmaceutical compositions and, in particular, as ikk inhibitors
abstract The invention relates to products of formula (I) in which: R2, R3 and R4 represent one hydrogen and the others represent hydrogen, halogen, alkyl or alkoxy; R5 represents hydrogen or halogen; R1 represents hydrogen, cycloalkyl, alkyl, alkenyl or alkynyl, all of which being optionally substituted; A represents a single bond or -CH2-CO-NR6- with R6 being selected among the values of R 1; the cycle containing Y (or (Y) cycle)) having 4 to 8 members with Y representing O, S, SO, SO2, N-R7 ((Y) cycle) that can contain a carbon bridge), C=O or the dioxolane therefor, CF2, CH-OR8, CH-NR8R9, and; R7 represents hydrogen, cycloalkyl, alkyl, CH2-alkenyl or CH2-alkynyl, all of which being optionally substituted; R8 represents hydrogen, alkyl, cycloalkyl or heterocycloalkyl, all of which being optionally substituted, these products existing in all isomeric forms and the salts. The invention also relates to the use of the aforementioned derivatives as medicaments, in particular, as IKK inhibitors.
priorityDate 2005-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 49.