| abstract |
THE INVENTION RELATES TO ANTHRANILIC ACID AMIDES, TO A METHOD FOR THE PRODUCTION THEREOF, TO THEIR USE AS A MEDICAMENT, AND TO PHARMACEUTICAL PREPARATIONS CONTAINING THESE ANTHRANILIC ACID AMIDES. THE ANTHRANILIC ACID AMIDES CONSIST OF COMPOUNDS OF FORMULA (I) : IN WHICH R(1) TO (R7) HAVE THE MEANINGS AS CITED IN THE CLAIMS, ACT UPON THE KV1.5 POTASSIUM CHANNEL, AND INHIBIT A POTASSIUM STREAM DESCRIBED AS AN "ULTRA-RAPIDLY ACTIVATING DELAYED RECTIFIER" IN THE HUMAN CARDIAC ATRIUM. THE COMPOUNDS ARE THEREFORE ESPECIALLY SUITED AS NOVEL ANTIARRHYTHMIC ACTIVE SUBSTANCES, PARTICULARLY FOR TREATING AND PREVENTING ATRIAL ARRHYTHMIAS, E.G. ATRIAL FIBRILLATION AF OR ATRIAL FLUTTER |