abstract |
THE INDAZOLE COMPOUNDS WHICH MODULATE AND / OR INHIBIT THE ACTIVITY OF CERTAIN PROTEINS - KINASES ARE DESCRIBED. THESE COMPOUNDS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ARE CAPABLE OF TRANSDUCING A TYROSINE - KINASE SIGNAL AND THUS MODULATING AND / OR INHIBITING AN UNWANTED CELL PROLIFERATION. THE INVENTION ALSO CONCERNS THE THERAPEUTIC OR PROPHYLACTIC USE OF PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND THE METHODS OF TREATING CANCER AND OTHER CONDITIONS ASSOCIATED WITH ANGIOGENIA AND / OR CELLULAR PROLIFERATION, SUCH AS RETINOPATHY DIABE ON NEOFORMATION OF BLOOD VESSELS, RHUMATOID POLYARTHRITIS AND PSORIASIS, BY ADMINISTERING EFFECTIVE QUANTITIES OF THESE COMPOUNDS. |