| abstract |
The present invention relates to pharmaceutical compositions of 6- (6-hydroxymethyl- pyrimidin-4-yloxy) -naphthalene-1-carboxyfic acid (3-trifluoromethyl-phenyl) -amide, to the use of 6- (6-hydroxymethyl-pyrimidin -4-yloxy) -naphthatene-1-carboxylic acid (3-trifluoromethyI-phenyl) -amide and compositions of 6- (6-hydroxymethyl-pyrimidin-4-yloxy) -naphthalene-1- carboxylic acid (3-trifluoromethyi-phenyi ) -amide in therapeutic applications, especially indications with a dysregulation / overexpression of VEFG, (neo) -vascularisation and VEGF driven angiogenesis and to methods for manufacturing such compositions, the invention further relates to specific forms of 6- (6-hydroxymethyl-pyrimidin -4-yloxy) - aphthalene-1- carboxyiic acid (3-triflu for romethyl-phenyl) -amide and to the manufacturing and use of such forms. The present invention also relates to a new process to produce 6- {6-hydroxymethyl- pyrimidin-4-yloxy) -naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl) -amide. |