| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_251f2686051db450ca11541fe3de499d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-20 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0018
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate |
2005-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ecbe06306b6e63ad006a53e037b9309
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7764a0d8eaf29c4a4808d0a8ecc658c1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f42f238c3f4b939ed78c0d9481a9078e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_107e248ec6e12adfa946e8c621893fb5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3cf752ae9c7f38d07c91f48431d624e9 |
| publicationDate |
2006-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
SV-2006002212-A |
| titleOfInvention |
A-BETAQ PRODUCTION REF. 2004658-0076 |
| abstract |
AN IMPROVED SYSTEM FOR THE LARGE-SCALE PRODUCTION OF PROTEINS AND / OR A-BETA IN CELL CULTURE, PARTICULARLY IN MEANS CHARACTERIZED BY ONE OR MORE THAN: I) A CUMULATIVE CONCENTRATION OF AMINO ACID MORE THAN 70 MM; II) A CUMULATIVE MOLAR GLUTAMINE AT A PROPORTION OF ACCUMULATIVE ASPARAGINE LESS THAN 2; III) A CUMULATIVE MOLARA GLUTAMINE FOR TOTAL CUMULATIVE PROPORTION OF THE AMINO ACID UNDER SOME 0.2; IV) AN ACCUMULATIVE MOLAR INORGANIC ION TO THE TOTAL CUMULATIVE AMINO ACID PROPRTION BETWEEN 0.4 TO 1; OR IS PROPORTIONED V) A COMBINED CUMULATIVE CONCENTRATION OF GLUTAMINE AND ACCUMULATIVE ASPARAGINE BETWEEN ABOUT 16 AND 36 MM. THE USE OF SUCH SYSTEM ALLOWS THE HIGH LEVELS OF A-BETA PRODUCTION AND INCREASES THE ACCUMULATION OF CERTAIN INDESEABLE FACTORS AS AMMONIUM AND / OR LACTATE. ADDITIONALLY, THE CULTURE METHODS THAT INCLUDE A TEMPERATURE CHANGE ARE PROVIDED, TYPICALLY INCLUDING A DECREASE IN THE TEMPERATURE WHEN THE CULTURE HAS ACHIEVED 20-80% OF ITS MAXIMUM CELL DENSITY. ALTERNATIVELY OR ADDITIONALLY, THIS INVENTION PROVIDES THE MOSO METHODS THAT, AFTER REACHING A MAXIMUM, THE LEVELS OF LACTATE AND / OR AMMONIUM IN THE CULTURE DECREASE IN EXTRA TIME |
| priorityDate |
2004-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |