| abstract |
THE INVENTION PROVIDES A FORMULA COMPOUND (I), SEE FORMULA (I) OR THE PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME, IN WHICH Y1, Y2, Y3 AND Y4 ARE SELECTED INDEPENDENTLY BETWEEN N, CH, ETC .; R1 ES H, RENT C1-8, ETC .; Q1 IS A MONOCICLIC OR BICYCLE AROMATIC RING OF 5 TO 12 MEMBERS THAT OPTIONALLY CONTAINS UP TO 4 SELECTED HETEROATOMES BETWEEN OR, N AND S, ETC .; A IS A MONOCICLIC AROMATIC RING OF 5-6 MEMBERS THAT OPTIONALLY CONTAINS UP TO 3 SELECTED HETEROATOMES BETWEEN O, N AND S, ETC .; B IS RENT C1-6 OPTIONALLY REPLACED WITH AN OXO GROUP, ETC .; W ES NH, O, ETC .; R2 ES H, C1-4 RENT, ETC .; R2 ES H, C1-4 RENT, ETC .; Z IS A MONOCICLIC OR BICYCLE AROMATIC RING OF 5 TO 12 MEMBERS THAT OPTIONALLY CONTAINS UP TO 3 SELECTED HETEROATOMES BETWEEN OR, N AND S, ETC .; L IS HALO, RENT C1-4, ETC .; M ES O, 1 O 2; R3 AND R4 ARE SELECTED INDEPENDENTLY BETWEEN H AND RENT C1-4; ES H RENT C1-4, ETC .; Q2 IS A MONOCICLIC OR BICYCLE AROMATIC RING OF 5-12 MEMBERS, OR A TRICICLIC RING, OPTIONALLY CONTAINING UP TO 3 SELECTED HETEROATOMES BETWEEN OR, N AND S, ETC .; THESE COMPOUNDS ARE USEFUL FOR THE TREATMENT OF MEDICAL CONDITIONS MEDIATED BY PROSTAGLANDINAS SUCH AS PAIN, FEVER OR INFLAMMATION, ETC .; THIS INVENTION ALSO PROVIDES A PHARMACEUTICAL COMPOSITION THAT INCLUDES THE PREVIOUS COMPOUND. |