| abstract |
THE PRESENT INVENTION REFERS TO DERIVATIVES OF 2-AMINOPIRIDINE OF FORMULA I :, SEE FORMULA, OR PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME, IN WHICH YB ARE EACH INDEPENDENTLY H, OR TOGETHER, AYB FORM A CONDENSED RING TO THE RING , BEING SAID SATURATED OR UNSATURATED RING AND CONTAINING 5 TO 7 ATOMS IN THE RING, WHERE SUCH ATOMS IN THE RING CAN OPTIONALLY UNDERSTAND FROM 1 TO 2 HETEROATOMES SELECTED INDEPENDENTLY FROM THE GROUP CONSIDERED BY ME, NUMBER OR TWO, ADVANCING RINGS ARE NOT HETEROATOMOS; X IS OXYGEN OR A SIMPLE LINK; AND IS RENT (C1-C6); R1 IS HYDROGEN, RENT (C1-C6) OR A GROUP (RENT C1-C6) REPLACED WITH -NR2R3 IN WHICH AND R3 ARE SELECTED WELL INDEPENDENTLY FROM THE GROUP CONSTITUTED BY H, RENT, ARILO, ARALQUILO, OR TETRAHYDRONAFTALENO, BEING SUCH GROUP ARILO OR SUCH ARYL GROUP OF SUCH GROUP ARALQUILO FENILO OR DIFFERENT GIFT ARALQUILO GROUP OF ONE TO SIX CARBON ATOMS AND BEING A LINEAR OR RAMIFIED CHAIN, AND BEING SUCH ARILO GROUP, SUCH TETRAHYDRONAFTALENO OR SUCH ARILO OF SUCH ARALQUILO GROUP, NITRO, CIANO-CINOX, AINO-CYYL (AINO) -C4), OR R2 AND R3 FORM, TOGETHER WITH THE NITROGEN TO WHICH THEY ARE UNITED, A HETEROCICLICAL RING, OR A CYCLICAL OR BICYCLE RING THAT IS SATURATED OR INSURED. THE COMPOUNDS OF THE INVENTION HAVE THE CAPACITY OF INHIBITING THE ACTIVITY OF THE SYNTHESES OF NITRIC OXIDE (US), AND THEREFORE, ARE USEFUL IN THE TREATMENT OF DISEASES, STATES AND DISORDERS OF THE CENTRAL NERVOUS SYSTEM, AMONG OTHERS. |