| abstract |
THE PRESENT INVENTION REFERS TO A PHARMACEUTICAL COMPOSITION IN THE FORM OF TABLETS OR CAPSULES PROVIDES A COMBINATION OF TEMPORAL AND SPACE CONTROL OF RELEASE OF A DRUG TO AN EFFECTIVE THERAPEUTICAL RESULTS. THE PHARMACEUTICAL COMPOSITION INCLUDES A DRUG, A GAS GENERATING COMPONENT, A DILATING AGENT, A VISCOSE AGENT, AND OPTIONALLY A GEL-FORMING POLYMER. THE EXPANSION AGENT BELONGS TO A GROUP OF COMPOUNDS KNOWN AS SUPER-DISINTEGRATORS (FOR EXAMPLE: THE LINK CRUZADO POLYVINYLPYROLIDONE OR SODIUM CARAT-GALLY, ELGARA DE GIANT EL LUADOR, GUAI ELGUERO, GUAI EL GUAI CAUSING THE TABLET OR CAPSULE TO FLOAT TO BE RETAINED IN THE STOMACH OR IN THE UPPER PART OF THE SMALL INTESTINE (SPACE CONTROL). AT THE SAME TIME THE MATRIX OF THE HYDRATED GEL CREATES A WAY OF TORTUOUS DIFFUSION FOR DRUGS, WHICH RESULTS IN A SUSTAINED RELEASE OF DRUGS (TEMPORAL CONTROL). A PREFERRED FORMULATION OF CYPRROFLOXATION ONLY GIVEN ONCE A DAY INCLUDES 69.9% CIPROFLOXATION BASE, 0.34% SODIUM ALGINATE, 1.03% JANTIC GUM, 13.7% DEZYRENE, 12.1% DEIVIN POLY OPTIONALLY OTHER PHARMACEUTICAL EXCIPIENTS, THE FORMULATION IS IN THE FORM OF TABLETS COATED OR NOT, OR IN CAPSULES |