| abstract |
2-Aminopyrimidones which are histamine H 2 - antagonists having the structuren in which Het is a nitrogen-containing 5- or 6-membered fully unsaturated heterocyclic group, m is 0 or 1, Y is methylene, oxygen or sulphur, n is 2 or 3, Z is hydrogen or lower aikyl, A is an alkylene group or an alkylene group interrupted by oxygen or sulphur, and B is hydrogen or a methyl, cycloalkyl, heteroaryl, phenyl, naphthyl, benzodioxolyl or dihydroben- zodioxinyl group, are prepared by a process in which an amine Het-(CH 2 ) m Y(CH 2 ) n NH 2 is reacted with a 2-nitroaminopyrimidone of structuren The new 2-nitroaminopyrimidone intermediates are prepared by reacting nitroguanidine with an oxoester RO 2 C-CH(COZ)-A-B where R is lower alkyl. |