| abstract |
The compounds of formula: <IMAGE> are prepared from corresponding carboxylic acids of formula: <IMAGE> by a reaction capable of converting the carboxyl group to a functional derivative. The meaning of the symbols is given in Claim 1. Of the compounds obtained, those which have a 15-tetrahydropyranyloxy group can be hydrolysed, those which have a hydroxyl group can be esterified, and those which have a secondary alcohol group in position 15 can be oxidised to the corresponding ketone or dehydrated in position 15, 16; finally, the double bond in position 13, 14 and the triple bond of an alkynyl group in position 15 can be hydrogenated. The compounds display a hypotensive activity; they can be employed in the treatment of hypertension (high blood pressure) and of circulatory disorders. |