http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SU-1757469-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-00 |
| filingDate | 1987-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1992-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2adbd039f233ec5fe9e351934fe4e5dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0a97675fb26b32bcd5d90bde69d2277 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea810489f9414276618181aa14ac7ac2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b98150faa97d14f4d6877b6db51643c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0764210301c3ef6b36fd83fac763fb66 |
| publicationDate | 1992-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SU-1757469-A3 |
| titleOfInvention | Method of a stable crystalline cephalosporin form preparation |
| abstract | The invention relates to heterocyclic compounds, in particular, the preparation of a stable crystalline form of cephalosporins of a common fi I © J3 X-JHg-CH-C (0) -Y-H-5-CHg-C (CH2bl and C-C (SP-0 orb) (CH3) - (CHa) 4, which do not contain the D2-isomer and are used in the process of conversion to cephalosporin antibiotics. The aim is to create new stable salts of the indicated class. Synthesis is carried out with methanol treatment of the compound II -tH-ciDi-t4-tH -t-cHrctc rt 9-c fr l CH h CH |) CWVNH where n is 0 or 1, in methylene chloride, when n 1, or in 1,1,2-trichlorotrifluoroethane, when n O (to remove silyl groups) with subsequent acidification of HCI or HJ. In this case, when in the salt Ntr (6) and n 0, the process is carried out in 1,1,2-trichlorotrifluoroethane. In another case, the reaction is carried out from compound f-ly 111 (CH iSitO-Ctoan-NH-CH-CWl-y-iH-S-CHt-CICHiJK-ttOi-O-SifCH) and pyridine or 1-methylpyrrolidine in ChteCIa- medium n is 1 or 0. or in 1,1,2-trichlorotrifluoroethane when n is 0, followed by treatment with methanol (to remove silyl groups) and acidification with HCl or HJ. In this case, when NiP1 is 1-methyl-pyrrolidinium and n 0, the process at both stages is carried out in 1,1,2-trichlorotrifluoroethane. New substances in the synthesis of cephalosporic antibiotics make it possible to exclude the release stages of carboxyl groups, Table 1. (L S of 2 O chy |
| priorityDate | 1985-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.