http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SU-1744946-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ee39f5102fef3572387d7a4b18ad3058 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C275-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C273-18 |
| filingDate | 1989-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2035b024c553dbea1aeaf523746b3a24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9dda1d6086de50b4d4f252a9845ac4e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f01c74fd0f8e3711abda7bc09953a6e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bc4d3a4cfc7a20290826a6a74d15354 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd10f2343945faa7262a2043e0d9679f |
| publicationDate | 1998-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SU-1744946-A1 |
| titleOfInvention | A method for producing a mixture of isomers of 9- (2-chloroethyl) -7-nitrose-L-homotitrulline and 9- (2-chloroethyl) -9-nitroso-l-homotitroline |
| abstract | The invention relates to urea derivatives, in particular the preparation of a mixture of 9- (2-chloroethyl) -7- (or 9) nitroso-L-homocytrulline isomers (I and II) used in pharmaceuticals. The goal is to increase the yield of the target product with a certain isomeric composition. Synthesis is carried out by treating lysine KOH and copper sulfate in an aqueous medium, followed by the introduction of the carbamoylating agent 1,3-bis- (2-chloroethyl) -1-nitrosourea at 32-36 ° C, decomposition of the complex with oxalic acid in the presence of HCl, nitrosation of NaNO into HCl at pH 1 - 2. The resulting mixture of isomers is divided in two stages: from a water-alcohol solution of hydrochloric acid, followed by neutralization with aqueous NH4 to pH 5.2 - 5.4 at minus 2 - plus 2C; crystallization at minus 10 - minus 12C and a mass ratio of the copper complex, water and alcohol in the first stage 1: 4.5 - 5: 2 - 2.4 and in the second - a mixture of isomers, water and alcohol 1: 3.8 - 4, 2: 1,1 - 1,3. In this case, the average yield of a mixture of isomers with a ratio of compounds I and II of 23–27 (%): 47–73 (%), the content of the basic substance 98–99.7% is 38.9%. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2503657-C1 |
| priorityDate | 1989-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.