http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SU-1676453-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d709e3167fa2f99a1803c9cfeb0aca63 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02 |
| filingDate | 1988-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1991-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32f2309b08e0706f2d9cffc5f4da7d1c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61c5d277b49d7f1ed85703329c0231d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93ae1c151a3ca4b78649e3fe510deadd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d86c038f69609349d698eee589526490 |
| publicationDate | 1991-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SU-1676453-A3 |
| titleOfInvention | Method for preparation of fused pyrasol derivatives or theirs pharmaceutically accessible salts |
| abstract | The invention relates to heterocyclic substances, in particular the preparation of compounds of the general f-ly I: where E is O or K C Su-alkyl, phenyl; RJ (independent) -H, halogen,.-Alkyl, C C -agasoxy; Q-H, C (0) -NHR & when Kv-C, -C-alkyl or (CHj) n-RJ- with RjT-phenyl (possibly mopo-or disubstituted with halogen, CFj, N0, C-alkyl) and n 0 or 1, or their pharmaceutically acceptable salts with immunomodulatory activity that can be used in medicine. The goal is to create new, more active substances of the specified class. Synthesis is carried out by the reaction of compounds; Nenya f-ly II with the compound f-ly III: NЈC-CH2-Q, VN-NR2-R3 C where Y is a chemically active substituent of the carboxy group; in an inert solvent in the presence of a basic agent at a temperature of from room temperature to 60 ° C. If necessary, the obtained compound with Q-H is reacted with compound f-ly IV:. The preparation of the necessary salts is carried out by the appropriate treatment of compound F. I. New compounds have low toxicity (mice over 400 mg / kg) and are active at a dose of 0.5-10 mg / kg. 1 tab. (Л С о VJ Ол GJ СО |
| priorityDate | 1987-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.