http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SU-1660356-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4eb30b8ec6fc4e0b443ac0b8789ae5d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C273-18 |
| filingDate | 1989-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8ca58f04ed78073d0c3e549f262a60e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3e594fb8baceea12fa1254b19e6f65f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93e54846a58d532869f698e0eb49c475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3220472ef8044e82395eb2e710ba7042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_356fdd0f3364f876ca3a0e29b91df470 |
| publicationDate | 1998-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SU-1660356-A1 |
| titleOfInvention | The method of obtaining 1,3-bis- (2-chloroethyl) -1-nitrosourea |
| abstract | The invention relates to substituted nitrosoureas, in particular the preparation of 1,3-bis- (2-chloroethyl) -1 -Nitrosourea, which is used in medicine as an antitumor drug. The goal is to simplify the process. It is carried out by nitrosation of 1,3-bis- (2-chloroethyl) urea with sodium nitrite in a mixture of hydrochloric and glacial acetic acids at a volume ratio of 1: 3-13 while cooling, followed by precipitation of the desired product directly from the reaction mixture with a temperature from 0 to -10 ° C with water gradually added to the mixture. These conditions can reduce the number of stages and eliminate the use of flammable petroleum ether when a high yield of the target product is reached (up to 91.6%). with d and ON |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3214075-B1 |
| priorityDate | 1989-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.