| abstract |
An arylpiperazinyl-alkylenephenyl-p-heterocyclic compound, useful in the treatment of psychotic disorders, of the formula- <CHEM> or a pharmaceutically-acceptable acid-addition salt thereof, wherein:- Ar is phenyl, 3-trifluoromethylphenyl, 3-cyanopyridyl, naphthyl, or a five- or six-membered aromatic heterocyclic ring, said ring being attached to the N atom of the adjacent piperazinyl group by a carbon atom and having one nitrogen, oxygen or sulfur, or two nitrogens one of which may be replaced by oxygen or sulfur, or said heterocyclic ring is condensed with benzo, said naphthyl, heterocyclic and benzoheterocyclic rings being optionally substituted by one fluoro, chloro or trifluoromethyl substituent, said substitution in the case of said naphthyl and benzoheterocyclic rings being in the ring not attached to the piperazinyl group; n is 2, 3 or 4; and "Het" is a group of the formula:- <CHEM> in which R is H or C1-C3 alkyl, and Y is -H, -OH, -SH, -NH2, C1-C3 alkyl or C1-C3 alkylamino. |