| abstract |
The invention relates to peptides, in particular neuropeptides common f-ly: N-acetyl-D-Met-Pro-Arg-R, where R = H or Gly-NH, with behavioral activity that can be used in medicine. The goal is to create new, more active and less toxic substances of the specified class. The synthesis, for example, of a tetrapeptide, is carried out using dicyclohexylcarbodiimide with the addition of hydroxybenzotriazole in peptide condensation reactions. Boc-Pro-Arg is condensed with glycylamide, and the resulting tripeptide is released by treatment with HCl in ethyl acetate. By reacting N-acetyl-D-methionine with Pro-Arg-Gly-NH in the presence of these substances, the corresponding tetrapeptide is obtained. These peptides have a more pronounced stimulating effect on the processes of memory, motor activity at doses of 10 to 100 times smaller than for vasopressin, and the available method of administration, as well as less toxicity. |